Create a dialogue between two people. Describe and critique two Essay

Create a dialogue between two people. Describe and critique two perspectives on morality - Essay Example I believe in utilitarian ethics and I would like to discuss it with you and maybe learn about your moral basis.† Steve was delighted by the topic and replied, â€Å"I have also noted our differences and attributed it to diversity. Discussing our moral values would be important to our interpersonal relationship and will improve our perspective on our environments. I believe in deontology ethics. Could you please tell me about your ethical perspective?† David: â€Å"Utilitarian ethical perspective is based on the concept maximum good to a majority of members of the society (Brooks and Dunn 183). It informs judgment on a act, whether of commission or of omission, based on effects on members of the society and therefore means that morality of an act is determined after members of the society have interacted with the act and its effects, both positive and negative have been observed. The act is then said to be unethical if realized bad effects on members of the society are m ore significant than benefits from the act. It is however considered moral if greater benefits can be derived from it and this identifies two perspectives to determining ethics in an act, the extent of effects on people and the number of people that the act affect. Utilitarianism also relates to decisions whose implementation has effects on people. Rule utilitarianism explains this by offering rules that can lead to maximum good in a society. A decision to restrict a person’s right to smoke in a public place is for example moral under utilitarian ethics because while it may infringe the smoker’s need and may be cause distress, it will be beneficial to many other people I the immediate environment through ensuring clean air and protecting the people’s lives (Kanniyakonil 65- 66).† David: â€Å"I should have been keen to note that your judgments are based on consequentialism. My ethical perspective, deontology, is however a rule based perspective to moral j udgment. The perspective associates morality with duty that is expected of people in a society and is based on social rules. It is different from your ethical perspective because it disregards consequences of an act or a decision. An act that is consistent with established rules is for example considered ethical despite its negative consequence to members of the society and an act that contradicts existing rules and obligations is considered immoral irrespective of the net benefit that in which it results. considering your example of smoking in a public place and suppose that a the society allows people to smoke in public places, then the act of smoking is considered moral regardless of the air pollution and its associated effects on people’s health (Basford and Slevin 214, Showler 21)† David: â€Å"Reliance on rules for judging decisions and actions has the benefits in fair judgment and this is contrary to the scope of your utilitarian approach that also appear to be subjective. One of my concerns with utilitarian approach to ethics is the lack of a suitable measure for benefits and harm of an act. There is no standard measure and this compromises reliability and fairness because some people may be more sensitive than others are while some may exaggerate consequences. It is also difficult to identify population segments that have been affected by an act or a decis

Understand the role of the Social Care Worker Essay Example for Free

Understand the role of the Social Care Worker Essay Ai: Three differences between a working relationship and a personal relationship are: A working relationship is a relationship that remains professional within the workplace where as a personal relationship you may spend time with someone out of work hours. A personal relationship is a relationship in which information sharing is unlimited yet a working relationship information sharing is on a need to know basis with colleagues, residents and other professionals. A personal relationship is one of choice with someone you like and share common interests where as a working relationship may be with someone you may not usually be friends with but have to form a team with that person and work under certain rules. Aii: One example of a working relationship in an adult social care setting is the relationship between carer and resident. This relationship is important as you need to maintain a professional duty of care. Another example would be between the senior in charge and the G.P. When a G.P comes to see a resident that is poorly they are relying on the carers and the senior in charge to inform them of any changes in that resident so they need to be professional at all times. Aiii: It is important that social care workers work in partnership with individuals using the service and their families because we all have a common interest in doing whats best for the individual and keeping them from harm. The service user is there because they may not have someone that can look after them the way they need therefore involving families and help to improve the way you care for them. For example, you might think that â€Å"Doris† may like going to bed at 10pm every night but is always very tired during the day after getting up at 7am. The family can tell you that in fact â€Å"Doris† used to go to bed at 9pm and likes getting up at 8am when she was at home. It is  essential to establish and maintain a good working relationship with family as they can also help to overcome any communication issues you may have with that service user and also find out their preferences for food choices. It’s all about person centered care. The resident is less open to abuse as there are clear boundaries and expectations of the social care workers relationship. Aiv: Three ways of working that can help improve partnership working are: Involve the resident in all decision making regarding their care plans for example what time they like to go bed, whether they prefer a bath or shower and if they like to go out on planned outings Give them a choice at meal times and what they would like to wear that day Try to promote their independence by giving them as much do to by themselves as possible for them without allowing them to struggle and that someone is there if they need a hand. Av: When people with different views, skills and expertise work together there may be disagreements about the best way forward. Here is five different skills or approaches that may help resolve conflict. 1.By listening to each side may help you and others see that your way may or not be the best way 2.By compromising you can figure out the best outcome by thinking about all possible solutions 3.Stay calm. If you start to lose your temper than the problem isnt going to get resolved 4.Communication is key. By talking it through you all may come up with a suitable solution as a team 5.By using a person centered approach everyone has the residents best interests at heart. Avi: Two ways in which you could obtain support and advice about working in partnership and resolving conflicts are by talking to colleagues and senior members of staff. They may have more experience and knowledge when dealing with conflicts or partnership working. The manager can help you by offering a professional solution to conflicts and follow the complaints procedure. If necessary the manager will enable you to access conflict management training or any other training that may be relevant. Task B Bi: Agreed ways of working means: That you should keep up to date with legislation Follow policies and procedures Work within your job description Work within your code of conduct Work in line with care standards Bii: Its important to have up to date details regarding the agreed ways of working because if a piece of legislation changes, as they do quite regularly, you need to know what is expected of you. When I was pregnant in order to keep myself, my colleagues and the residents safe my job description changed slightly and my new agreed ways of working were updated regularly. These changed back when I returned to work after having the baby. Biii: Where I am not trained in giving medication if I was to carry out this task I would be liable if something was to go wrong. I do not carry out tasks that are not within my job description and that i have not been trained in as these are not within my agreed ways of working. Its important to follow these guidelines so that I do not cause harm to myself, my colleagues or the residents.

Insulin and Erythropoietin Production

Insulin and Erythropoietin Production Insulin is a protein (polypeptide) discovered in 1921 by Banting with the pancreas being the site of its production. It is made up of 51 amino acids, divided into 2 chains; A and B, bonded by disulfide linkages. Chain A is made up of 21 amino acids with an intra-disulphide linkage, while chain B is made up of 30 amino acids (4). Why Insulin? Insulin is important in glucose metabolism, and is being used for the treatment of Diabetes mellitus; a metabolic disorder of glucose in the body. Initially, Insulin from animals was used to treat this disorder however nowadays synthesized human Insulin is being used, this is because; it is fast absorbed by the body, it has less allergic reactions, it contains less impurities, and it produces good results (3). Recombinant process of producing Insulin Synthetic Insulin was first produced in 1983 through genetic Engineering, which involve extraction of the human DNA (1), once extracted, the gene for Insulin is isolated, and enzymes are used to cut it. The gene is then cut using enzymes and put into the plasmid of a vector, where in most cases E. coli plasmid is used. Since Insulin contains two chains, two pieces of DNA are extracted, and the genes for the two chains are linked to ÃŽ ² galactosidase enzyme of the bacteria. The plasmids formed are then inserted into a host cell E. coli and sealed using another enzyme called ligase. And the host on replicating produces the enzymes each containing one of the two chains each. Production is followed by extracting and purifying the chains which are mixed in a reaction to reconstitute the disulphide bridges (1). ESCHERICHIA COLI AS RECOMBINANT INSULIN HOST Entero-bacillus, gram-negative E. coli is about 1 2ÃŽ ¼m, it can survive in the presence/absence of oxygen, and it also grows in an optimum pH and temperature of 7.0 and 37oC respectively. It utilizes glucose as its major carbon source and can also use other carbon sources like pyruvate, glycerol, acetate, and other sugars. K-12 and B strains are mostly used in the laboratory (20) Reasons for choosing E. coli Genetic Engineering technologies were developed using E. coli as a role organism, and so, the genetics of E. coli are well known among other microorganisms, as such its the most used organism for the production of different proteins (14). Moreover E. coli has a well known safety and production abilities, stable plasmid, controllable promoter, cheaper and easily cultured (6), E. coli also has fast growth rate, its easy to handle, and has well known fermentation skills and the ability to produce high protein content (14). That is why most of the proteins licensed recently by FDA and EMEA, were produced in E. coli (5). With these, and the fact that Insulin is a simple polypeptide (protein) which does not require glycosylation for its bioactivity and stability, E. coli carrying the plasmids for production of insulin will be used as the host for the production of Insulin Strain and plasmids: BL21 strain containing the pMYW-A and pMYW-B plasmids and temperature repressor ÃŽ »-c1857, will be used for insulin production (21). Growth strategy The various growth strategies that will be used to grow E. coli in order to make it happy and produce the desired product (11) include: Medium: E. coli needs nutrients like carbon, nitrogen and others; thus a carbon source; glycerol will be provided since its cheaper and more soluble than glucose (12), a source of nitrogen in the form of ammonium sulphate will also be provided. However such nutrients in large quantities can inhibit the growth of E. coli, as such a defined medium that contain optimum concentrations 20gl-1 glycerol and 2gl-1 ammonium sulphate will be used (11). The medium will also consist of the following; 3gl-1 KH2PO4, 1gl-1 MgSO4.7H2O, 0.8gl-1 citrate, and 6gl-1 K2HPO4 (23). Some trace elements will also be added to the medium. (23) Process and culture-strategies: E. coli will be grown submerged in a sterile controlled stirred tank reactor, and fed-batch will be used as the growth strategy so as to avoid accumulation of acetate which can be inhibits its growth, and reduce the production of the insulin (18). The growth strategy will be divided into two; initially batch mode will be used to initiate growth, after which the fed-batch exponential feeding will be used to produce the insulin (21). After adapting the medium and feeding method, oxygen transfer rates (OTRs) had to be increased through a suitable bioreactor design and over-head pressure (16). Large scale reactors usually reach high ORTs using air and normal aeration pressure, and so the oxygen partial pressure (pO2) will be increased by adding pure oxygen to the air-stream entering the reactor, thus increasing its oxygen transfer rates (16) DO will be maintained at 40% of air saturation and aeration rate at 1vvm. Foaming arising due to large number of cells and high aeration-rates will be solved by use of impellers for stirring simultaneously at 300rpm and the use of antifoam (ucolub N115) (16, 21). The process temperature and pH will be maintained at 30oC and 6.8 respectively so as to avoid partial proteolysis of the insulin protein. Bioreactor Design: Bioreactor vessel is usually cylindrical and made up of stainless steel. It is composed of impeller for stirring, Air sparger is placed at the bottom of the vessel for introduction of air, it has some inlets for introduction of acid/alkali for pH control and also for introduction of antifoams, nutrients and inoculum; It is also has pH, DO and temperature probes for sensing (22), Microbial activity during fermentation usually produces heat, so the bioreactor design must allow for removal of heat, and this can be achieved by cooling with jackets and coils (16) Bioreactors must also be designed in a way that it can withstand high temperature and pressure and to allow cleaning-up and sterilizing (22). Growth analysis Temperature, pH, DO, foam, partial oxygen and carbon dioxide pressures, will be analysed on-line, other parameters like biomass, will be analysed by using optical density (OD600) and dry cell weight (offline). Cell viability will be analysed by using flow cytometry, the concentrations of substrates and metabolites by enzymatic methods while insulin will be analysed using electrophoresis methods like SDS-PAGE, and ELISA, while its purity will be determined by HPLC (8). Limitations/Problems There are several problems that may arise during processing and can limit the use of this organism for Insulin production, these are; Poor secretion because of the structure of its membrane (and tough cell wall), small amount of foldases, chaperones and increased concentrations of proteases, leading to low productivity (7). Solutions to this problem include all measures taken to increase quality of secretion and production such as: Use of secretion systems like the system of ÃŽ ±-haemolysin (7) co-expression after co-cloning of foldases and chaperones (13) Improving the rates of gene-expression and using proteases deficient mutants like BL21 (18). use of E. coli mutants that are deficient of cell-wall (12) Limited post translational-modifications; including disulfide-linkage formation, which is important for the insulin stability and biological activity (9). Solutions to this problem include; Production of insulin with altered amino acid sequences through genetic engineering (9) Using E. coli mutants to enhance the formation of disulfide linkages e.g. Origami (15) iii. Exporting proteins into the periplasm which has disulphide bonding mechanisms (19). Codon biases; due to large quantities of exact transfer-RNAs found in E. coli, the codons in the human-genes are often different from those that are found in this organism. This results in inefficient expression of some of these rare codons by the organism resulting in an unexpected protein synthesis termination or wrong incorporation of the amino acids (12). This problem can be solved by replacing codons that are rare in the desired gene by codons that are often found in the E. coli and by co-expressing the rare transfer-RNAs (15). Acetate is usually formed as a by-product, and is inhibitory to growth of the cells (20). Solution is by using a fed-batch feeding method and by limiting DO level (11). Another problem is that large proteins are often obtained in an insoluble form (5); forming aggregates called inclusion bodies; IBs (20). This can be solved by adjustment of temperature, increasing the strength of the promoter, adjusting the number of plasmids, concentrations of the inducer, and the composition of the media (9). Erythropoietin EPO EPO is a glycoprotein that is produced in the renal cortex of the kidney (10, 11). It has also being shown to be present in the brain, spleen, liver and the lungs (7, 17). It is made up of 165 amino acids of about 18kDa (25), with a number of carbohydrates linked to the polypeptide through O and N glycosidic-bonds giving the glycoprotein a total weight of 34kDa.Two disulphide linkages hold the molecule together (15) and the carbohydrates are responsible for the stability of the glycoprotein in-vivo,and increasing its half-life in the body (24). Why EPO? EPO functions to regulate the amount of red blood cells (RBC) in the blood by controlling the proliferation and differentiation of its immature cells to mature cells (1, 2, 22,). It is also involved in the growth and formation of blood vessels, and healing of wounds (6), it functions in the brain is not clear, but studies showed the glycoprotein to have some protective effects (18). Because of these functions EPO has being used in the treatment of anaemia caused by kidney failure and other causes (25). Recombinant production of EPO Despite its importance, EPO in body is found in very small amounts and mostly in the urine (4), as such there is the requirement to produce EPO in large amounts, this leads to the work of isolating the glycoprotein from the urine (12, 21), and was used to identify its amino acid sequences, and synthesis of its DNA (9, 12), furthermore the human erythropoietin genes were cloned by Lin et al. (17), and consequently recombinant human EPO (rhuEPO) was produced in 1985 using CHO cells (14, 16). Chinese -Hamster- Ovary (CHO-Cells) as rhuEPO host: These are epithelial cells derived from the ovary of Chinese hamster (a mammal). They grow well in culture and looks like cobble stones. The cells usually attach to a surface available but can be grown in suspension (20). CHO cells are grown best at 37oC and at pH 7.4; they are cultured in a suitable complex medium which can support their growth for many generations (20). CHO cell lines are now available from cell culture collections like the American type culture collection; ATCC. Moreover human EPO expression plasmids are now also commercially available, and are usually used for production of EPO using the CHO cells (27). Reasons for choosing CHO-cells Karthik et al. (13) showed that CHO-cells are being used extensively in the industries for the production of many proteins, because they have demonstrated, to possess some qualities like: They can modify biological products post-translationally; Proteins produce in CHO-cells have high glycosylation quality making them compatible and stable (13) Safety of the product; Studies in 1989 have shown that most viruses do not multiply in CHO-cells (13) Ability to adapt easily and be grown in suspension (13). Products can now be purified to contain less contaminant (13). CHO cells have being used for a long time; as such much data has being accumulated for regulatory reasons (13). They are easy to manipulate genetically (13). The isolation of cells deficient in Dihydrofolate-reductase enzymes leads to stable clones selection and genes amplification to increase production (13). With all these, and the fact that EPO is a glycoprotein that requires glycosylation for its stability and activity, recombinant CHO cells are chosen to produce EPO. Cell lines and plasmids: Cell lines which have the capability of glycosylating proteins (Pro-5), harboring the pGEX-HET-puro expression plasmid, will be used to produce the recombinant human erythropoietin (27). Growth strategy Medium: Complex culture medium will be provided with; Glucose as a source of carbon and energy, Amino acids as source of nitrogen, Salts will be included to make the solution isotonic Vitamins and hormones will be added as co-factors Serum is usually added to the culture medium to enhance the growth of the cell (20), but has the following disadvantages: It chemicals are not defined and can cause cell growth inconsistency between batches (20) It is very expensive (20) The serum may contain proteins which can be difficult to separate and purify from the proteins secreted by the cells during downstream processing (20) It increases foaming and can be a source of contamination by viruses. (20) Therefore a serum-free (SF) media (16) will be used for the growth of the E. coli. Process and culture-strategies: The cells will be grown adherent on micro-carriers in a sterile controlled packed bed reactor, and perfusion method of production where some amounts of the medium is removed and replaced by fresh one and the cells are grown slowly will be used (28); because it was found to improve the glycosylation of the proteins more than fed-batch where there is fast growth of cells, (8). Before, many processes were run in a simple batch method, but nowadays, Perfusion or fed-batch methods are mostly employed and higher products are now realized (22). The production will be carried out in two stages; the growth stage and the production stage. Normally stirring will be kept at 100 to 150 rpm, foaming will be avoided by adding Pluronic F68 (16).Temperature will be maintained at 37oC initially during growth and then reduced to 33oC during production, as was shown to increase the overall protein production, while maintaining the quality of the glycoprotein (3, 26). pH w ill be kept at 7.1 initially and then reduced to 6.8 (8, 26), by passing CO2 gas to the culture or by addition of concentrated sodium-bicarbonate solution in low quantities, because CO2 is also toxic to the cells and can also affect the production of EPO (20). In order to avoid the depletion of oxygen, the oxygen transfer rates (OTRs) will be increased above its utilization rate, with a constant supply of pure oxygen and air, while DO will be maintained at 20-50% of air saturation (20). Bioreactor Design: Since the cells are big and fragile, the design of the bioreactor has to be considered. Mammalian cell culture bioreactors are designed with bottoms that are round and are usually made up of glass/stainless steel (20). The impellers are usually marine or pitched blade types fitted at the end of mechanical drives shafts so that both vertical and horizontal mixing are allowed at low stirring-rates (20). Temperature is controlled through coiled pipes or open ended fermenter jacket (20). pH, DO and temperature probes are used for sensing and have both air inlet and outlet for respiration. Growth Analysis Temperature, pH and DO will be monitored on-line, because cells are immobilized, biomass formed cannot be measured directly therefore it will be monitored by measuring rate of glucose consumed daily and the rate of lactate produced (28) Cell viability by flow cytometry, Glucose, glutamine, and lactate concentrations will be analysed using multi-parameter Bio-analytical system (26); while ammonia formed as waste product of amino acid metabolism, will be analysed by colorimetric assay and by the use of detection-kit (26). EPO formed will be analysed using HPLC to determine its purity and its quality by Isoelectric focusing, SDS, and Bradford assay (26). The activity of EPO will be analysed by bioassay and by the use of protein assay-kit (27) Limitations/Problems. There are many limitations associated with CHO cells culture processes and they include; They are fragile and highly sensitive to shear stress caused by agitation and bubble because the cells are large and have only cell membrane (20). This is usually solved using a suitable bioreactor-design and use of Pluronic F68 (20). They need a complex medium including serum which can cause problems in the downstream processing and is expensive (20). Solution to this is by using serum- free media (24, 25). Low yield of proteins have been produced from these cells, the productivity using the microbes being higher than the use of these cells. They also have slow growth rates (13). The problem of low productivity and slow growth rates can be solved through selecting cell lines that are better and optimizing cultural-strategies. Ammonia and lactate are generated during growth and can inhibit growth and also affect glycosylation (8). Solution is by optimizing the strategies of feeding and by monitoring (8). Glycosylation differences may arise from the EPO produced in the CHO-cells and the human EPO as seen in the way the two are sialylated terminally, as a result that the CHO-cells are not able to express an enzyme called alpha-2,6, sialyltransferase (27). Solution is by the use of CHO-cells harboring alpha-2, 6, sialyltransferase-cDNA expression-cassettes (27). REFERENCES: 1. Alcamo, I., DNA Technology; the Awesome-Skill. Farming-dale. New York: Academic Press. (2001). 2. Banting Grolier Electronic publishing www.littletree.com.au/dna.htm accessed on 30/12/2010 3. Carbs information, www.carb-information.com/insulin-synthetic.htm accessed on 30/12/ 2010. 4. Charce, R.E., and Frank, B.H., Research, Production and Safety of Biosynthetic Human Insulin. (1993). www.littletree.com.au/dna.htm accessed on 30/12/2010. 5. Ferrer-Miralles N. Domingo-Espà ­n, J. Corchero, J.L. Và ¡zquez, E. and Villaverde, A. Microb. fact. for recombinant pharmaceuticals, Microbial factories , 8:17, 2009. 6. Fox, S. Improved processes and new capacity for pipeline to commercial production. Biopharmaceutical contract manufacturing, Volume 1 (report). High Tech Business Decisions: San Jose, CA. 2005 7. Genschev, I., Dietrich, G., Goebel, W.,The E. coli alpha-hemolysin secretion system and its use in vaccine development. Trends Microbiol. 10: 39-45. 2002 8. Hewitt C.J., Nebe-von Caron G., Axelsson B., McFarlane C.M, Nienow A.W Studies related to the scale-up of high-cell-density E. coli fed-batch fermentations using multi-parameter flow cytometry: effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration. Biotech. Bioeng. 70: 381-390. 2000 9. Hite P.F, Barnes A.M.J.P.E. Exhuberance over Exubera. Clinical Diabetes 24: 110-114. 2006. 10. Jana, S., Deb, J.K. Strategies for efficient production of heterologous proteins in Escherichia coli. Appl. Microbiol. Biotech. 67: 289-29. 2005. 11. Joseph S., and Raphael F., growing E. coli to high- cell density-A historical perspective on method development Biotech. Advances 23: 345-357 2005. 12. Korz D.J, Rinas U., Hellmuth K, Sanders E.A, Deckwer W.D. Simple fed-batch technique for high cell density cultivation of E. coli. J Biotechnology, 39: 56-65. 1995. 13. Kujau, M.J., Hoischen, C., Riesenberg, D., Gumpert, J. Expression and secretion of functional mini-antibodies McPC603scFvDhlx in cell-wall-less L-form strains of Proteus mirabilis and E. coli: a comparison of the synthesis capacities of L-form strains with E. coli producer strain. Appl. Microbiol. Biotech. 49: 51-58. 1998. 14. Lund, P.A. Microbial molecular chaperones. Advanc. Microbiol. Physiol. 44: 93-140. 2001 15. Makrides S.C. Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol. Rev. 60: 512-5388. 1996. 16. Meyer, H.P. Brass, J. Jungo, C. Klein, J. Wenger, J. and Mommer, R. an emerging Star for Therapeutic and Catalytic Protein Production. Bioprocess International. 2008. 17. Nacelle, G. J. V. and Coppel, R. L. Reshaping Life; Key Issues in Genetic Engineering, Novo-Nordisk Promotional Brochure. Melbourne: Melbourne University Press. 1989. 18. Schmidt, F.R. Recombinant expression systems in pharmaceutical industry. Appl. Microbiol. Biotech. 65:363-37. 2004. 19. Wacker M., Linton D., Hitchen P.G., Nita-Lazar M., Haslam, S.M., North, S.J., Panico M., Morris H.R., Dell A., Wren, B.W., Aeb, M. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science 298:1790-1793. 2002. 20. Demain, L. A., and Vaishnav, P. Production of recombinant proteins by microbes and higher organisms. Biotech.Advan. 27: 297-306. 2009. 21. Schmidt, M., Raman Babu, K., Khanna, N., Marten, S., Rinas, U., Temperature- induced production of recombinant human insulin in high cell density culture of recombinant Escherichia Coli. Journal of Biotech. 68:71-83. 1999. 22. Ratledge, C. and Kristiansen, B. Basic biotechnology. Cambridge: Cambridge university press. 2001. 23. Tabandeh, F., Shojaosadati, S.A., Zomorodipour, A., Khodabandeh, M., Sanati, M.H., Yakhchali, B. Heat induced production of human growth hormone by high cell density cultivation of recombinant E. coli. Biotech. Letters. 26: 245-250. 2004.

The Stoic Tradition Essay -- Philosophy Religion Essays

The Stoic Tradition In the approximate year of 320 B.C., one could be walking down the street with a high probability of passing a house where several men would be gathered out on the porch. It is likely that this was a gathering of individuals discussing philosophy. The gatherings became a more common occurrence, and since they would take place out on the porches, the school of philosophy derived from them takes its name from the Greek stoa, or porch. The ideology of that movement is henceforth known as Stoicism. Also, the Stoics have come to use the statement made by Socrates as the cornerstone of their judgments, being that "no harm can come to a good man." However, this concept is taken a bit further by the Stoics, as they deduce it to symbolize the eventually complete rejection of worldly things. These things they also deem "things which cannot be controlled." The current inquiry considers some of the chief notions of the Stoics, but more specifically it focuses upon one important question: what does it mean to follow nature for the Stoics? To answer this question, the testimonies of several of the Stoics are pooled and examined together in the end. Not only does this inquisition illustrate chief attributes of Stoicism, but those attributes are eventually evaluated in light of their coherence as well. One of the main ideas which form part of the answer as to what it means to follow nature for the Stoics is the following of an intended trajectory. As the oak tree strives to achieve its natural form of the best oak tree that it can become, it is upon its natural trajectory of reaching its potential. So too, borrowing from Aristotle, humans have the potential of becoming excellent in their own right through... ...become cattle. This position forms a contradiction between the endeavor to attain human excellence, become a noble being, and the want to give back. This position is, once again, not human. For one cannot become the best possible oak tree and at the same time reach the highest possible potential of a human being. One is either human, or a plant. Works Cited Aurelius, Marcus. "Meditations." Ancient Philosophy. 3rd Ed. Philosophic Classics, vols. 1. Baird, Forrest E., and Walter Kaufman. Upper Saddle River: Prentice Hall, 2000. Epictetus. "Encheiridion." Ancient Philosophy. 31 Ed. Philosophic Classics, vols. 1. Baird, Forrest E., and Walter Kaufman. Upper Saddle River: Prentice Hall, 2000. Plato. "Apology." Ancient Philosophy. 3rd Ed. Philosophic Classics, vols. 1. Baird, Forrest E., and Walter Kaufman. Upper Saddle River: Prentice Hall, 2000. 82-100.

His Talk, Her Talk

It is no secret that men and women have marriage problems. A big source of that happens to be communication issues. Men tend to not be interested in what the women wants to talk about. Same goes with women, they may not be as interested in male conversations or men do not give as much detail as the women would like. That is why many are attending marriage counseling. For couples in marriage counseling a good essay to read is â€Å"His talk, her talk†, by Joyce Maynard. It talks about how there are different ways men and women talk. Males tend to talk about general things and skip details.Females will usually talk about a certain topic and stay on it. Men will usually just skip from topic to topic. Another essay that would be a good read is â€Å"Man to man, women to women†, by Mark A. Sherman and Adelaide Hags. They talk about how males and females talk about different things. Women tend to talk about kids, jobs, husbands and other female things. Men will usually just s tick to sports, work, and anything else that happens to be in their surroundings, as in anything that happens to be on the news. So men and women differ in conversation.The essay I would most recommend would be â€Å"His talk, her talk†, by Joyce Maynard. It basically states that it is okay for a husband and wife do not have the most in common when it comes to conversations. Women and men talk about different things. The other spouse is just supposed to accept that. That would help others open their eyes. In conclusion both essays are good, but that is the one I would recommend. The one bad thing about it is that it is from one women’s perspective. One situation does not speak for everyone. However it does speak for the majority. So it would help many couples in marriage counseling.

Chickens by Barbara Clarke essays

Chicken's by Barbara Clarke essays In the story Chickens by Barbara Clarke there are many themes including jealousy, abuse, relationships and depression. As the reader I think that the main theme of this story is depression. In this essay I will show in detail how the writer has explored this theme in the text. The story is in the first person narrative and is about the thoughts and feelings of the narrator after she had killed her husband. As a child she was very unhappy at home, she was shouted at and sometimes sent to bed without her tea. She was also unhappy at school because she had a lot to be envious of, especially other girls in her class, they were picked up by their Mothers at home time. As an adult she started to work in a chicken factory where her job was to kill chickens, she did not enjoy her job because of this and also because of the way her boss treated her. She felt that her husband did not love or care for her, he had beaten her making her feel insignificant and unloved. With the story being in the first person narrative, this giving the story a confessional feel to it, the reader understands what the narrator thinks and feels about herself. Throughout this piece of text the narrator talks about her unhappy past. She compares her personality as a child to how she feels about herself as an adult, I was such a nice girl, wasnt that what they said. This quote shows that the narrator doesnt see herself as others see her, being a pleasant character. From her childhood she had been treated as worthless disappointment and had began to believe that she was. The reader acknowledges these feelings through the way she puts herself down. She seems to consider that her personal qualities are not worth anything. Didnt make a difference, didnt get me one of those nice jobs. She feels disappointed in herself and is very unhappy with the job she has. Although the narrator was a well-behaved girl it di...